HiScreen Capto Core 700

HiScreen Capto Core 700
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Número de artículo.: GE17548115 194,00 € para 1 Paquete más IVA (21%) más costes de envío

HiScreen Capto Core 700

HiScreen Capto Core 700
HiScreen Capto Core 700 is a ready-to-use 4,7 ml column, prepacked with Capto Core 700, for intermediate purification and polishing of viruses and other large biomolecules in flow-through mode, Each bead has a ligand-activated core and an outer layer without ligands, The layer prevents the large targets from entering into the beads whereas proteins and other impurities enter into the core where they bind to the hydrophobic and positively charged octylamine ligands, HiScreen columns are easy used together with a chromatogtaphy system such as ÄKTA design HiScreen Capto Core 700 Capto Core 700 is designed for intermediate purification and polishing of viruses and other large biomolecules. The novel core bead technology and multimodal, octylamine ligand give Capto Core 700 dual functionality, size exclusion, and binding chromatography in one chromatography medium (resin). For intermediate purification and polishing of viruses and other large biomolecules (Mr 700 000) in flowthrough mode. Novel core bead technology allows efficient capture of contaminants while target molecules are collected in the flowthrough. Significantly improved productivity and higher flow rates compared with gel filtration methods. Straightforward optimization due to flowthrough chromatography and robust performance. Convenient small-scale purification, process development, and scale-up using prepacked HiTrap and HiScreen columns. Capto Core 700 is composed of a ligand-activated core and inactive shell. The inactive shell excludes large molecules (cut off ~ Mr 700 000 [700 kDa]) from entering the core through the pores of the shell. These larger molecules are collected in the column flowthrough while smaller impurities bind to the internalized ligands. The core of each bead is functionalized with ligands that are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core. The multimodal ligands ensure strong binding with most impurities over a wide range of pH and salt concentrations. Bound impurities are removed from the beads by cleaning-in-place (CIP) procedures using NaOH and in most cases, a solvent. Capto Core 700 is available in various pack sizes for packing columns and in convenient, prepacked 1 ml HiTrap and 4.7 ml prepacked HiScreen formats. HiTrap and HiScreen columns can be connected in series for increased capacity and are convenient to use when developing an efficient and robust separation method.

Package Content: 1 PCE

Reference Num.: GE17548115
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